Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.

The Journal of biological chemistry - 13 Oct 2006

Benjannet Suzanne, Rhainds David, Hamelin Josée, Nassoury Nasha, Seidah Nabil G

Abstract excerpt

PCSK9 is the ninth member of the proprotein convertase (PC) family. Some of its natural mutations have been genetically associated with the development of a dominant form of familial hyper- or hypocholesterolemia. The exact mechanism of action of PCSK9 is not clear, although it is known to enhance the intracellular degradation of the low density lipoprotein (LDL) receptor in acidic compartments, likely the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum
Share to Furin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipoproteins, LDL

Share to Proprotein Convertase 9

Share to Proprotein Convertases

Share to Protein Processing, Post-Translational

Share to Serine Endopeptidases

Share to trans-Golgi Network

Source

Identifiers

PMID: 16912035
DOI: 10.1074/jbc.M606495200

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.PMID 16912035Read ↗

In Vivo Evidence That Furin from Hepatocytes Inactivates PCSK9Semantic proximity Read ↗

Molecular basis of PCSK9 function.Semantic proximity Read ↗

PCSK9: a key modulator of cardiovascular health.Semantic proximity Read ↗

A novel splicing variant of proprotein convertase subtilisin/kexin type 9.Semantic proximity Read ↗

The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9.Semantic proximity Read ↗

Characterization of novel mutations in the catalytic domain of the PCSK9 gene.Semantic proximity Read ↗

The PCSK9 decade.Semantic proximity Read ↗

The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol.Semantic proximity Read ↗

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture.Semantic proximity Read ↗

Isolation and characterization of the circulating truncated form of PCSK9Semantic proximity Read ↗

[PCSK9: Structure and function. PCSK9 and low-density lipoprotein receptor. Mutations and their effects].Semantic proximity Read ↗

Genetics of the First Seven Proprotein Convertase Enzymes in Health and DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.