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Article

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.

eLife - 9 Apr 2013

Chen Xiao-Wei, Wang He, Bajaj Kanika, Zhang Pengcheng, Meng Zhuo-Xian, Ma Danjun, Bai Yongsheng, Liu Hui-Hui, Adams Elizabeth, Baines Andrea, Yu Genggeng, Sartor Maureen A, Zhang Bin, Yi Zhengping, Lin Jiandie, Young Stephen G, Schekman Randy, Ginsburg David

Abstract excerpt

The secretory pathway of eukaryotic cells packages cargo proteins into COPII-coated vesicles for transport from the endoplasmic reticulum (ER) to the Golgi. We now report that complete genetic deficiency for the COPII component SEC24A is compatible with normal survival and development in the mouse, despite the fundamental role of SEC24 in COPII vesicle formation and cargo recruitment. However, these animals...

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Share to COP-Coated Vesicles
Share to Dyslipidemias

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, 129 Strain

Share to Proprotein Convertase 9

Share to Proprotein Convertases

Share to Receptors, LDL

Share to Serine Endopeptidases

Share to Vesicular Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23580231
DOI: 10.7554/eLife.00444
PMCID: PMC3622177

Genes

SEC24A
PCSK9
LDLR
SEC13
SEC23A
SEC24B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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