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Article

Internalized PCSK9 dissociates from recycling LDL receptors in PCSK9-resistant SV-589 fibroblasts.

Journal of lipid research - 1 Feb 2014

Nguyen My-Anh, Kosenko Tanja, Lagace Thomas A

Abstract excerpt

Secreted PCSK9 binds to cell surface LDL receptor (LDLR) and directs the receptor for lysosomal degradation. PCSK9 is potent at inducing LDLR degradation in cultured liver-derived cells, but it is considerably less active in immortalized fibroblasts. We examined PCSK9 trafficking in SV-589 human skin fibroblasts incubated with purified recombinant wild-type PCSK9 or gain-of-function mutant PCSK9-D374Y with...

Read the complete abstract on PubMed

Topics

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Share to Endocytosis
Share to Intracellular Space
Share to Lysosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proprotein Convertase 9

Share to Proprotein Convertases

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Share to Receptors, LDL

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Source

Open in PubMed Open full text

Identifiers

PMID: 24296664
DOI: 10.1194/jlr.M044156
PMCID: PMC3886665

Genes

PCSK9
LDLR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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