Article

Hepatic inactivation of murine <i>Surf4</i> results in marked reduction in plasma cholesterol

2022-08-03

Abstract excerpt

PCSK9 negatively regulates low-density lipoprotein receptor (LDLR) abundance on the cell surface, leading to decreased hepatic clearance of LDL particles and increased levels of plasma cholesterol. We previously identified SURF4 as a cargo receptor that facilitates PCSK9 secretion in HEK293T cells (Emmer et al., 2018). Here, we generated hepatic SURF4-deficient mice ( Surf4 fl/fl Alb-Cre + ) to investigate the ph...

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Literature Corpus work: 141a1c46-be4f-5a98-a466-30fb4f8267a9
DOI: 10.1101/2022.08.01.502222

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