Article
While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable.
Molecular and cellular biology - 1 Dec 2003
Plowman Sarah J, Williamson D James, O'Sullivan Maureen J, Doig Jennifer, Ritchie Ann-Marie, Harrison David J, Melton David W, Arends Mark J, Hooper Martin L, Patek Charles E
Abstract excerpt
In mammals, the three classical ras genes encode four highly homologous proteins, N-Ras, H-Ras, and the isoforms K-Ras 4A and 4B. Previous studies have shown that K-ras is essential for mouse development and that while K-ras 4A and 4B are expressed during development, K-ras 4A expression is regulated temporally and spatially and occurs in adult kidney, intestine, stomach, and liver. In the present study, the...
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