Article

The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

2018-05-31

Abstract excerpt

<h4>ABSTRACT</h4> Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that plays an important role in regulating plasma cholesterol and cardiovascular disease risk. PCSK9 secretion uniquely depends on the cytoplasmic COPII protein SEC24A, suggesting the presence of a transmembrane ER cargo receptor mediating this interaction. Here, we report a novel approach that combines proximity-depende...

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Literature Corpus work: efc98ce9-d42d-52be-a38c-8b166023eb79
DOI: 10.1101/336016

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