Article

Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

2020-09-18

Abstract excerpt

Circulating polymers of alpha1-antitrypsin (α1AT) are chemo-attractant for neutrophils and contribute to inflammation in pulmonary, vascular and adipose tissues. Cellular factors affecting the intracellular itinerary of mutant polymerogenic α1AT remain obscure. Here, we report on an unbiased genome-wide CRISPR/Cas9 screen for regulators of trafficking of the polymerogenic α1AT H334D variant. Single guide RNAs tar...

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Literature Corpus work: df973052-dd45-50d3-bd53-7ed53be5771f
DOI: 10.1101/2020.09.17.301119

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