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Article

CaMKII versus DAPK1 Binding to GluN2B in Ischemic Neuronal Cell Death after Resuscitation from Cardiac Arrest.

Cell reports - 7 Jan 2020

Buonarati Olivia R, Cook Sarah G, Goodell Dayton J, Chalmers Nicholas E, Rumian Nicole L, Tullis Jonathan E, Restrepo Susana, Coultrap Steven J, Quillinan Nidia, Herson Paco S, Bayer K Ulrich

Abstract excerpt

DAPK1 binding to GluN2B was prominently reported to mediate ischemic cell death in vivo. DAPK1 and CaMKII bind to the same GluN2B region, and their binding is mutually exclusive. Here, we show that mutating the binding region on GluN2B (L1298A/R1300Q) protected against neuronal cell death induced by cardiac arrest followed by resuscitation. Importantly, the GluN2B mutation selectively abolished only CaMKII, but...

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Identifiers

PMID: 31914378
DOI: 10.1016/j.celrep.2019.11.076
PMCID: PMC6959131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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