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Article

Genetic Mutation of GluN2B Protects Brain Cells Against Stroke Damages.

Molecular neurobiology - 1 Apr 2018

Tang Na, Wu Jianhua, Zhu Houze, Yan Honglin, Guo Yu, Cai You, Yan Huanhuan, Shi Yan, Shu Shu, Pei Lei, Lu Youming

Abstract excerpt

Immediately following ischemia, glutamate accumulates in the extracellular space and results in extensive stimulation of its receptors including N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors. A large amount of Ca2+ influx directly through the receptor-gated ion channels which leads to Ca2+ overload and triggers several downstream lethal reactions. As a...

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Source

Identifiers

PMID: 28456939
DOI: 10.1007/s12035-017-0562-y

Genes

DAPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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