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Article

Differential regulation by ATP versus ADP further links CaMKII aggregation to ischemic conditions.

FEBS letters - 19 Nov 2009

Vest Rebekah S, O'Leary Heather, Bayer K Ulrich

Abstract excerpt

CaMKII, a major mediator of synaptic plasticity, forms extra-synaptic clusters under ischemic conditions. This study further supports self-aggregation of CaMKII holoenzymes as the underlying mechanism. Aggregation in vitro was promoted by mimicking ischemic conditions: low pH (6.8 or less), Ca(2+) (and calmodulin), and low ATP and/or high ADP concentration. Mutational analysis showed that high ATP prevented...

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Source

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Identifiers

PMID: 19840793
DOI: 10.1016/j.febslet.2009.10.028
PMCID: PMC2790910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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