Article
Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit.
Cell reports - 6 Jul 2021
Yong Xuan Ling Hilary, Zhang Lingrui, Yang Liming, Chen Xiumin, Tan Jing Zhi Anson, Yu Xiaojun, Chandra Mintu, Livingstone Emma, Widagdo Jocelyn, Vieira Marta M, Roche Katherine W, Lynch Joseph W, Keramidas Angelo, Collins Brett M, Anggono Victor
Abstract excerpt
NMDA receptor (NMDAR)-dependent Ca2+ influx underpins multiple forms of synaptic plasticity. Most synaptic NMDAR currents in the adult forebrain are mediated by GluN2A-containing receptors, which are rapidly inserted into synapses during long-term potentiation (LTP); however, the underlying molecular mechanisms remain poorly understood. In this study, we show that GluN2A is phosphorylated at Ser-1459 by...
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