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Article

Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors.

Cell reports - 28 Mar 2013

Sanz-Clemente Antonio, Gray John A, Ogilvie Kyle A, Nicoll Roger A, Roche Katherine W

Abstract excerpt

Synaptic activity triggers a profound reorganization of the molecular composition of excitatory synapses. For example, NMDA receptors are removed from synapses in an activity- and calcium-dependent manner, via casein kinase 2 (CK2) phosphorylation of the PDZ ligand of the GluN2B subunit (S1480). However, how synaptic activity drives this process remains unclear because CK2 is a constitutively active kinase, which...

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Identifiers

PMID: 23478024
DOI: 10.1016/j.celrep.2013.02.011
PMCID: PMC3615108

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PSD

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