Article
SAP102 mediates synaptic clearance of NMDA receptors.
Cell reports - 29 Nov 2012
Chen Bo-Shiun, Gray John A, Sanz-Clemente Antonio, Wei Zhe, Thomas Eleanor V, Nicoll Roger A, Roche Katherine W
Abstract excerpt
Membrane-associated guanylate kinases (MAGUKs) are the major family of scaffolding proteins at the postsynaptic density. The PSD-MAGUK subfamily, which includes PSD-95, PSD-93, SAP97, and SAP102, is well accepted to be primarily involved in the synaptic anchoring of numerous proteins, including N-methyl-D-aspartate receptors (NMDARs). Notably, the synaptic targeting of NMDARs depends on the binding of the PDZ...
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