Article
The CaMKII K42M and K42R mutations are equivalent in suppressing kinase activity and targeting.
PloS one - 1 Jan 2020
Tullis Jonathan E, Rumian Nicole L, Brown Carolyn Nicole, Bayer K Ulrich
Abstract excerpt
CaMKII is an important mediator of forms of synaptic plasticity that are thought to underly learning and memory. The CaMKII mutants K42M and K42R have been used interchangeably as research tools, although some reported phenotypic differences suggest that they may differ in the extent to which they impair ATP binding. Here, we directly compared the two mutations at the high ATP concentrations that exist within...
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