Article
Tau Tubulin Kinase TTBK2 Sensitivity of Glutamate Receptor GluK2.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2016
Nieding Kristina, Matschke Veronika, Meuth Sven G, Lang Florian, Seebohm Guiscard, Strutz-Seebohm Nathalie
Abstract excerpt
BACKGROUND/AIMS: Inherited, autosomal dominant spinocerebellar ataxia type 11 (SCA11) is caused by loss of function mutations of TTBK2 (tau tubulin kinase 2). Mutations observed in patients with SCA11 include truncated TTBK2(450). The present study explored the possibility that TTBK2 influences the function of the glutamate receptor GluK2. METHODS: GluK2 was expressed in Xenopus oocytes without and with...
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