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Article

Role of phosphorylated Y1252, Y1336 and Y1472 on NR2B subunits in hypoxia tolerance of neuronal cell in vitro.

Experimental brain research - 2 Dec 2024

Liu Xiaolei, Lu Xiaojun, Jiang Shuyuan, Gao Bing, Wang Peng, Zhu Hongwei, Hua Yunqi, Xie Wei, Jiang Xiangning, Shao Guo

Abstract excerpt

The N-methyl-D-aspartate (NMDA) receptors are related to the various functioning of the nervous system. It has been shown that the NR2B subunit plays an important role in neurological hypoxic/ischemic diseases by regulating NMDA receptor function. NR2B tyrosine phosphorylation is also an important regulatory mechanism for NMDA receptor function. However, the mechanism of NR2B tyrosine phosphorylation in...

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PMID: 39621125
DOI: 10.1007/s00221-024-06969-7

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