Article

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

2021-01-11

Abstract excerpt

NMDAR-dependent Ca 2+ influx underpins multiple forms of synaptic plasticity. In the adult forebrain, the majority of synaptic NMDAR currents are mediated by GluN2A-containing NMDARs. These receptors are rapidly inserted into synapses during LTP; however, the underlying molecular mechanisms remain poorly understood. Here we show that GluN2A is phosphorylated at Ser-1459 by CaMKIIα in response to glycine stimulati...

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Literature Corpus work: 3a1cd7cd-8a50-554f-a28c-24ed042a505d
DOI: 10.1101/2021.01.11.425709

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