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Article

Multi-regional sequencing reveals clonal and polyclonal seeding from primary tumor to metastases in advanced gastric cancer.

Journal of gastroenterology - 1 May 2020

Hirotsu Yosuke, Hada Masao, Amemiya Kenji, Oyama Toshio, Mochizuki Hitoshi, Omata Masao

Abstract excerpt

BACKGROUND: Tumor metastases to lymph nodes and distant organs are associated with worse prognosis in gastric cancer. However, little is known about the genetic profiles, subclonal architecture, and evolutional processes across primary tumors and metastases. METHODS: We analyzed the genetic alterations of 106 multiregional samples including primary tumors, lymph node metastases, and visceral metastases from 10...

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PMID: 31912238
DOI: 10.1007/s00535-019-01659-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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