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Article

Genomic landscape of paired primary and peritoneal metastatic lesions in gastric cancer highlights evolutionary dynamics and mutational drivers.

Journal of advanced research - 1 Mar 2026

Li Song, Zhang Weiwei, Yang Qian, Li Shuhan, Zhou Xuanyu, Wang Huan, Sun Ying, Liu Xiangyong, Ji Chunwang, Zhou Jianyuan, Nie Shulun, Wu Xuehui, Jiao Jianqiao, Dou Liliang, Hu Qinqin, Jiang Fan, Xu Qian, Dai Xin, Nan Zhaodi, Song Xinyu, Zhang Di, Zhao Wen, Wang Shuang, Chu Jiahui, Liu Lian

Abstract excerpt

INTRODUCTION: Peritoneal metastasis is a prevalent form of gastric cancer spread, often resulting in poor outcomes. Due to the lack of clinical recommendation for surgery, current omics studies are limited to analyzing suspending malignant cells in ascites using external controls, rather than examining peritoneal metastatic nodules alongside their paired primary tumors. OBJECTIVES: This study aims to elucidate...

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Source

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Identifiers

PMID: 40436141
DOI: 10.1016/j.jare.2025.05.043
PMCID: PMC12957787

Genes

DEK
ARID1A
CDH1
DUSP4
FADS6
FAT1
NDUFS7
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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