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Article

Single-cell DNA sequencing reveals a late-dissemination model in metastatic colorectal cancer.

Genome research - 1 Aug 2017

Leung Marco L, Davis Alexander, Gao Ruli, Casasent Anna, Wang Yong, Sei Emi, Vilar Eduardo, Maru Dipen, Kopetz Scott, Navin Nicholas E

Abstract excerpt

Metastasis is a complex biological process that has been difficult to delineate in human colorectal cancer (CRC) patients. A major obstacle in understanding metastatic lineages is the extensive intra-tumor heterogeneity at the primary and metastatic tumor sites. To address this problem, we developed a highly multiplexed single-cell DNA sequencing approach to trace the metastatic lineages of two CRC patients with...

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PMID: 28546418
DOI: 10.1101/gr.209973.116
PMCID: PMC5538546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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