Article

Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases

2019-10-31

Abstract excerpt

Metastasis is the primary cause of cancer-related deaths, but the natural history, clonal evolution and impact of treatment are poorly understood. We analyzed exome sequencing data from 457 paired primary tumor and metastatic samples from 136 breast, colorectal and lung cancer patients, including untreated (n=99) and treated (n=100) metastatic tumors. Treated metastases often harbored private ‘driver’ mutations wh...

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Literature Corpus work: a025ee48-101d-597a-bed1-0f1621ff4501
DOI: 10.1101/825240

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