Article
Genomic evolution and diverse models of systemic metastases in colorectal cancer.
Gut - 1 Feb 2022
Chen Hai-Ning, Shu Yang, Liao Fei, Liao Xue, Zhang Hongying, Qin Yun, Wang Zhu, Luo Maochao, Liu Qiuluo, Xue Zhinan, Cao Minyuan, Zhang Shouyue, Zhang Wei-Han, Hou Qianqian, Xia Xuyang, Luo Han, Zhang Yan, Yang Lie, Hu Jian-Kun, Fu Xianghui, Liu Bo, Hu Hongbo, Huang Canhua, Peng Yong, Cheng Wei, Dai Lunzhi, Yang Li, Zhang Wei, Dong Biao, Li Yuan, Wei Yuquan, Xu Heng, Zhou Zong-Guang
Abstract excerpt
OBJECTIVE: The systemic spread of colorectal cancer (CRC) is dominated by the portal system and exhibits diverse patterns of metastasis without systematical genomic investigation. Here, we evaluated the genomic evolution of CRC with multiorgan metastases using multiregion sequencing. DESIGN: Whole-exome sequencing was performed on multiple regions (n=74) of matched primary tumour, adjacent non-cancerous mucosa,...
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