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TP53 mutation is enriched in colorectal cancer liver metastasis in the context of polyclonal seeding.

Pathology, research and practice - 1 Aug 2022

Sun Wenjie, Sun Qingrong, Zhong Anjing, Lyne Anne-Marie, Huang Dongdong, Han Fengyan, Lai Maode, Zhang Honghe

Abstract excerpt

Cancer metastasis accounts for the majority of cancer motility burden. For colorectal cancer (CRC), the liver is the most common site of distant metastasis. It is still little known that cancer genomic mutations, which are a cell-intrinsic and heritable property, are enriched in CRC liver metastasis. Here, we try to answer the question in the context of polyclonal seeding. In this study, we sequenced 18 pairs of...

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Colorectal Neoplasms
Gene Frequency
Liver Neoplasms
Mutation
Tumor Suppressor Protein p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35679752
DOI: 10.1016/j.prp.2022.153958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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