Article
Mutation heterogeneity between primary gastric cancers and their matched lymph node metastases.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Mar 2019
Lee Han Hong, Kim Su Young, Jung Eun Sun, Yoo Jinseon, Kim Tae-Min
Abstract excerpt
BACKGROUND: The acquisition of an invasive phenotype by a tumor cell is a crucial step of malignant transformation. The underlying genetic mechanisms in gastric cancer (GC) are not well understood. METHODS: We performed whole-exome sequencing of 15 pairs of primary GC and their matched lymph node (LN) metastases (10 primary GCs with single matched LNs and 5 primary GCs with three LNs per case, respectively)....
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