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Article

Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases.

Nature genetics - 1 Jul 2020

Hu Zheng, Li Zan, Ma Zhicheng, Curtis Christina

Abstract excerpt

Metastasis is the primary cause of cancer-related deaths, but the natural history, clonal evolution and impact of treatment are poorly understood. We analyzed whole-exome sequencing (WES) data from 457 paired primary tumor and metastatic samples from 136 patients with breast, colorectal and lung cancer, including untreated (n = 99) and treated (n = 100) metastases. Treated metastases often harbored private...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32424352
DOI: 10.1038/s41588-020-0628-z
PMCID: PMC7343625

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