Article
Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Sept 2017
Wei Q, Ye Z, Zhong X, Li L, Wang C, Myers R E, Palazzo J P, Fortuna D, Yan A, Waldman S A, Chen X, Posey J A, Basu-Mallick A, Jiang B H, Hou L, Shu J, Sun Y, Xing J, Li B, Yang H
Abstract excerpt
BACKGROUND: Distant metastasis accounts for 90% of deaths from colorectal cancer (CRC). Genomic heterogeneity has been reported in various solid malignancies, but remains largely under-explored in metastatic CRC tumors, especially in primary to metastatic tumor evolution. PATIENTS AND METHODS: We conducted high-depth whole-exome sequencing in multiple regions of matched primary and metastatic CRC tumors. Using a...
Topics
- Colorectal Neoplasms
- Genetic Heterogeneity
- Humans
- Mutation
- Neoplasm Metastasis
- Neoplasm Seeding
- Exome Sequencing