Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure.

doi:10.1182/blood-2015-11-679167

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Article

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure.

Blood - 1 Sept 2016

Mossner Maximilian, Jann Johann-Christoph, Wittig Janina, Nolte Florian, Fey Stephanie, Nowak Verena, Obländer Julia, Pressler Jovita, Palme Iris, Xanthopoulos Christina, Boch Tobias, Metzgeroth Georgia, Röhl Henning, Witt Stephanie H, Dukal Helene, Klein Corinna, Schmitt Steffen, Gelß Patrick, Platzbecker Uwe, Balaian Ekaterina, Fabarius Alice, Blum Helmut, Schulze Torsten J, Meggendorfer Manja, Haferlach Claudia, Trumpp Andreas, Hofmann Wolf-Karsten, Medyouf Hind, Nowak Daniel

Abstract excerpt

Clonal evolution is believed to be a main driver for progression of various types of cancer and implicated in facilitating resistance to drugs. However, the hierarchical organization of malignant clones in the hematopoiesis of myelodysplastic syndromes (MDS) and its impact on response to drug therapy remain poorly understood. Using high-throughput sequencing of patient and xenografted cells, we evaluated the...

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Identifiers

PMID: 27268087
DOI: 10.1182/blood-2015-11-679167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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