Article
Clonal evolution in myelodysplastic syndromes.
Nature communications - 21 Apr 2017
da Silva-Coelho Pedro, Kroeze Leonie I, Yoshida Kenichi, Koorenhof-Scheele Theresia N, Knops Ruth, van de Locht Louis T, de Graaf Aniek O, Massop Marion, Sandmann Sarah, Dugas Martin, Stevens-Kroef Marian J, Cermak Jaroslav, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, de Witte Theo, Blijlevens Nicole M A, Muus Petra, Huls Gerwin, van der Reijden Bert A, Ogawa Seishi, Jansen Joop H
Abstract excerpt
Cancer development is a dynamic process during which the successive accumulation of mutations results in cells with increasingly malignant characteristics. Here, we show the clonal evolution pattern in myelodysplastic syndrome (MDS) patients receiving supportive care, with or without lenalidomide (follow-up 2.5-11 years). Whole-exome and targeted deep sequencing at multiple time points during the disease course...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.