Article

Therapy-Induced Clonal Selection as a Driver of Response to JAK Inhibitors in Myelofibrosis

2026-06-23

Abstract excerpt

Myelofibrosis (MF) originates from the stepwise acquisition of somatic mutations in Hematopoietic Stem and Progenitor Cells (HSPCs). Alongside driver events triggering JAK-STAT pathway hyperactivation, several additional mutations, usually affecting the epigenetic machinery, contribute defining therapeutic response. Specifically, JAK-inhibition (JAKi) relieves MF symptoms but rarely eradicates the neoplastic clon...

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Literature Corpus work: 690f8406-5a14-5e1a-9ed4-10e3829c1048
DOI: 10.64898/2026.06.20.733514

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