Article
Dynamics of clonal evolution in myelodysplastic syndromes.
Nature genetics - 1 Feb 2017
Makishima Hideki, Yoshizato Tetsuichi, Yoshida Kenichi, Sekeres Mikkael A, Radivoyevitch Tomas, Suzuki Hiromichi, Przychodzen Bartlomiej, Nagata Yasunobu, Meggendorfer Manja, Sanada Masashi, Okuno Yusuke, Hirsch Cassandra, Kuzmanovic Teodora, Sato Yusuke, Sato-Otsubo Aiko, LaFramboise Thomas, Hosono Naoko, Shiraishi Yuichi, Chiba Kenichi, Haferlach Claudia, Kern Wolfgang, Tanaka Hiroko, Shiozawa Yusuke, Gómez-Seguí Inés, Husseinzadeh Holleh D, Thota Swapna, Guinta Kathryn M, Dienes Brittney, Nakamaki Tsuyoshi, Miyawaki Shuichi, Saunthararajah Yogen, Chiba Shigeru, Miyano Satoru, Shih Lee-Yung, Haferlach Torsten, Ogawa Seishi, Maciejewski Jaroslaw P
Abstract excerpt
To elucidate differential roles of mutations in myelodysplastic syndromes (MDS), we investigated clonal dynamics using whole-exome and/or targeted sequencing of 699 patients, of whom 122 were analyzed longitudinally. Including the results from previous reports, we assessed a total of 2,250 patients for mutational enrichment patterns. During progression, the number of mutations, their diversity and clone sizes...
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