Clonal dynamics and copy number variants by single-cell analysis in leukemic evolution of myeloproliferative neoplasms.

doi:10.1002/ajh.27013

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Article

Clonal dynamics and copy number variants by single-cell analysis in leukemic evolution of myeloproliferative neoplasms.

American journal of hematology - 1 Oct 2023

Calabresi Laura, Carretta Chiara, Romagnoli Simone, Rotunno Giada, Parenti Sandra, Bertesi Matteo, Bartalucci Niccolò, Rontauroli Sebastiano, Chiereghin Chiara, Castellano Sara, Gentili Giulia, Maccari Chiara, Vanderwert Fiorenza, Mannelli Francesco, Della Porta Matteo, Manfredini Rossella, Vannucchi Alessandro Maria, Guglielmelli Paola

Abstract excerpt

Transformation from chronic (CP) to blast phase (BP) in myeloproliferative neoplasm (MPN) remains poorly characterized, and no specific mutation pattern has been highlighted. BP-MPN represents an unmet need, due to its refractoriness to treatment and dismal outcome. Taking advantage of the granularity provided by single-cell sequencing (SCS), we analyzed paired samples of CP and BP in 10 patients to map clonal...

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PMID: 37399248
DOI: 10.1002/ajh.27013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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