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Article

Development of a limited sampling strategy for the estimation of isoniazid exposure considering N-acetyltransferase 2 genotypes in Korean patients with tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Mar 2021

Lee Jihyun, Choi Giwon, Yang Seungwon, Ha Jung-Eun, Kim Eun Sun, Park Jong Sun, Lee Kyunghoon, Song Junghan, Lee Jae Ho, Lee Jangik I

Abstract excerpt

A limited sampling strategy (LSS) to estimate the exposure to isoniazid was developed considering N-acetyltransferase 2 (NAT2) genotypes in Korean patients with tuberculosis. The influence of the genotypes on the pharmacokinetics of isoniazid was also evaluated. A total of 33 participants participated in the study and received isoniazid 300 mg once daily. Evaluable participants consist of ten slow (SA), fourteen...

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Identifiers

PMID: 33548864
DOI: 10.1016/j.tube.2021.102052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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