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Article

A proposal for an individualized pharmacogenetic-guided isoniazid dosage regimen for patients with tuberculosis.

Drug design, development and therapy - 1 Jan 2015

Jung Jin Ah, Kim Tae-Eun, Lee Hyun, Jeong Byeong-Ho, Park Hye Yun, Jeon Kyeongman, Kwon O Jung, Ko Jae-Wook, Choi Rihwa, Woo Hye-In, Koh Won-Jung, Lee Soo-Youn

Abstract excerpt

BACKGROUND/AIM: Isoniazid (INH) is an essential component of first-line anti-tuberculosis (TB) treatment. However, treatment with INH is complicated by polymorphisms in the expression of the enzyme system primarily responsible for its elimination, N-acetyltransferase 2 (NAT2), and its associated hepatotoxicity. The objective of this study was to develop an individualized INH dosing regimen using a...

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Source

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Identifiers

PMID: 26491254
DOI: 10.2147/DDDT.S87131
PMCID: PMC4598210

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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