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Article

Population pharmacokinetic model of isoniazid in patients with tuberculosis in Tunisia.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Mar 2021

Fredj N Ben, Romdhane H Ben, Woillard J B, Chickaid M, Fadhel N Ben, Chadly Z, Chaabane A, Boughattas N, Aouam K

Abstract excerpt

AIMS: To develop a pharmacokinetic model of isoniazid (INH) concentration taking into account demographic factors and genetic variables [N-acetyltransferase 2 (NAT2) genotype], and to propose an initial INH dosage that could maximize the probability of achieving the desired INH concentration. METHODS: A retrospective analysis was undertaken of INH concentration data collected from patients with tuberculosis in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33476758
DOI: 10.1016/j.ijid.2021.01.033

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