Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Current Situation and Development Prospect of Whole-Genome Screening.

International journal of molecular sciences - 4 Jan 2024

Yang Caiting, Lei Yu, Ren Tinglin, Yao Mingze

Abstract excerpt

High-throughput genetic screening is useful for discovering critical genes or gene sequences that trigger specific cell functions and/or phenotypes. Loss-of-function genetic screening is mainly achieved through RNA interference (RNAi), CRISPR knock-out (CRISPRko), and CRISPR interference (CRISPRi) technologies. Gain-of-function genetic screening mainly depends on the overexpression of a cDNA library and CRISPR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endonucleases
Share to Gene Library
Share to Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Screening Assays

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 38203828
DOI: 10.3390/ijms25010658
PMCID: PMC10779205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Current Situation and Development Prospect of Whole-Genome Screening.PMID 38203828Read ↗

High‐throughput screens in mammalian cells using the CRISPR‐Cas9 systemSemantic proximity Read ↗

[High-throughput functional screening using CRISPR/Cas9 system].Semantic proximity Read ↗

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.Semantic proximity Read ↗

The application of CRISPR/Cas9–based genome-wide screening to disease researchSemantic proximity Read ↗

CRISPR-Cas9 library screening approach for anti-cancer drug discovery: overview and perspectivesSemantic proximity Read ↗

CRISPR-Cas systems for genome editing of mammalian cells.Semantic proximity Read ↗

CRISPR Editing in Biological and Biomedical Investigation.Semantic proximity Read ↗

CRISPR-Cas and CRISPR-based screening system for precise gene editing and targeted cancer therapySemantic proximity Read ↗

Progress and Perspective of CRISPR‐Cas9 Technology in Translational MedicineSemantic proximity Read ↗

Genome editing: A perspective on the application of CRISPR/Cas9 to study human diseases (Review)Semantic proximity Read ↗

Crispr-cas System: Classification, Benefits, Applications And FunctionSemantic proximity Read ↗

An Insight into Modern Targeted Genome-Editing Technologies with a Special Focus on CRISPR/Cas9 and its ApplicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.