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Article

High-resolution genotype-free mapping of genetic variation with CRI-SPA-Map.

Genome research - 6 May 2026

Lutz Sheila, Lawler Megan, Amidon Samuel, Albert Frank W

Abstract excerpt

Genetic variation within species shapes phenotypes, but identifying the specific genes and variants that cause phenotypic differences is costly and challenging. Here, we introduce CRI-SPA-Map, a genetic mapping strategy combining CRISPR-Cas9 genome engineering, selective ploidy ablation (SPA), and high-throughput phenotyping for precise genetic mapping with or without genotyping in the yeast Saccharomyces...

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Identifiers

PMID: 41871879
DOI: 10.1101/gr.281514.125
PMCID: PMC13445715

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