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Article

Genetic variation in EPHA contributes to sensitivity to paclitaxel-induced peripheral neuropathy.

British journal of clinical pharmacology - 1 May 2020

Marcath Lauren A, Kidwell Kelley M, Vangipuram Kiran, Gersch Christina L, Rae James M, Burness Monika L, Griggs Jennifer J, Van Poznak Catherine, Hayes Daniel F, Smith Ellen M Lavoie, Henry N Lynn, Beutler Andreas S, Hertz Daniel L

Abstract excerpt

AIMS: Chemotherapy-induced peripheral neuropathy (PN) is a treatment limiting toxicity of paclitaxel. We evaluated if EPHA genetic variation (EPHA4, EPHA5, EPHA6, and EPHA8) is associated with PN sensitivity by accounting for variability in systemic paclitaxel exposure (time above threshold). METHODS: Germline DNA from 60 patients with breast cancer was sequenced. PN was measured using the 8-item sensory subscale...

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Identifiers

PMID: 31823378
DOI: 10.1111/bcp.14192
PMCID: PMC7163383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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