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Article

A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2012

Baldwin R Michael, Owzar Kouros, Zembutsu Hitoshi, Chhibber Aparna, Kubo Michiaki, Jiang Chen, Watson Dorothy, Eclov Rachel J, Mefford Joel, McLeod Howard L, Friedman Paula N, Hudis Clifford A, Winer Eric P, Jorgenson Eric M, Witte John S, Shulman Lawrence N, Nakamura Yusuke, Ratain Mark J, Kroetz Deanna L

Abstract excerpt

PURPOSE: Sensory peripheral neuropathy is a common and sometimes debilitating toxicity associated with paclitaxel therapy. This study aims to identify genetic risk factors for the development of this toxicity. EXPERIMENTAL DESIGN: A prospective pharmacogenetic analysis of patients with primary breast cancer, randomized to the paclitaxel arm of CALGB 40101, was used to identify genetic predictors of the onset and...

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Identifiers

PMID: 22843789
DOI: 10.1158/1078-0432.CCR-12-1590
PMCID: PMC3445665

Genes

FGD4
EPHA5
FZD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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