Article

Genome-Wide Meta-Analysis Validates a Role for <i>S1PR1</i> in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy

2020-04-30

Abstract excerpt

Microtubule targeting agents (MTAs) are anticancer therapies commonly prescribed for breast cancer and other solid tumors. Sensory peripheral neuropathy (PN) is the major dose-limiting toxicity for MTAs and can limit clinical efficacy. The current pharmacogenomic study aimed to identify genetic variations that explain patient susceptibility and drive mechanisms underlying development of MTA-induced PN. A meta-anal...

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Literature Corpus work: 53a6a75e-2d14-5683-b074-8a12d892e3c3
DOI: 10.1101/2020.04.23.20076208

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