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Article

Genomewide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy.

Clinical pharmacology and therapeutics - 1 Sept 2020

Chua Katherina C, Xiong Chenling, Ho Carol, Mushiroda Taisei, Jiang Chen, Mulkey Flora, Lai Dongbing, Schneider Bryan P, Rashkin Sara R, Witte John S, Friedman Paula N, Ratain Mark J, McLeod Howard L, Rugo Hope S, Shulman Lawrence N, Kubo Michiaki, Owzar Kouros, Kroetz Deanna L

Abstract excerpt

Microtubule targeting agents (MTAs) are anticancer therapies commonly prescribed for breast cancer and other solid tumors. Sensory peripheral neuropathy (PN) is the major dose-limiting toxicity for MTAs and can limit clinical efficacy. The current pharmacogenomic study aimed to identify genetic variations that explain patient susceptibility and drive mechanisms underlying development of MTA-induced PN. A...

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PMID: 32562552
DOI: 10.1002/cpt.1958
PMCID: PMC7718413

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