Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.

Journal of medical genetics - 1 Sept 2013

Leandro-García Luis J, Inglada-Pérez Lucía, Pita Guillermo, Hjerpe Elisabet, Leskelä Susanna, Jara Carlos, Mielgo Xabier, González-Neira Anna, Robledo Mercedes, Avall-Lundqvist Elisabeth, Gréen Henrik, Rodríguez-Antona Cristina

Abstract excerpt

BACKGROUND: Peripheral neuropathy is the dose limiting toxicity of paclitaxel, a chemotherapeutic drug widely used to treat solid tumours. This toxicity exhibits great inter-individual variability of unknown origin. The present study aimed to identify genetic variants associated with paclitaxel induced neuropathy via a whole genome approach. METHODS: A genome-wide association study (GWAS) was performed in 144...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antineoplastic Agents

Share to Genome-Wide Association Study

Share to Kaplan-Meier Estimate

Share to Neoplasms

Share to Paclitaxel

Share to Peripheral Nervous System Diseases

Source

Identifiers

PMID: 23776197
DOI: 10.1136/jmedgenet-2012-101466

Genes

EPHA5
LIMK2
XKR4
EPHA4
EPHA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.PMID 23776197Read ↗

Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.Semantic proximity Read ↗

Polygenic risk of paclitaxel-induced peripheral neuropathy: a genome-wide association studySemantic proximity Read ↗

Genetic variation in EPHA contributes to sensitivity to paclitaxel-induced peripheral neuropathy.Semantic proximity Read ↗

A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.Semantic proximity Read ↗

Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.Semantic proximity Read ↗

Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy.Semantic proximity Read ↗

Single Nucleotide Polymorphisms of Paclitaxel-induced Peripheral Sensory Neuropathy in Chinese Han Population.Semantic proximity Read ↗

Whole-Exome Sequencing Reveals Defective CYP3A4 Variants Predictive of Paclitaxel Dose-Limiting NeuropathySemantic proximity Read ↗

Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).Semantic proximity Read ↗

The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis.Semantic proximity Read ↗

Genetic variation in Charcot-Marie-Tooth genes contributes to sensitivity to paclitaxel-induced peripheral neuropathy.Semantic proximity Read ↗

Genomewide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.