Article
Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).
The pharmacogenomics journal - 1 Aug 2014
Chhibber A, Mefford J, Stahl E A, Pendergrass S A, Baldwin R M, Owzar K, Li M, Winer E P, Hudis C A, Zembutsu H, Kubo M, Nakamura Y, McLeod H L, Ratain M J, Shulman L N, Ritchie M D, Plenge R M, Witte J S, Kroetz D L
Abstract excerpt
Peripheral neuropathy is a common dose-limiting toxicity for patients treated with paclitaxel. For most individuals, there are no known risk factors that predispose patients to the adverse event, and pathogenesis for paclitaxel-induced peripheral neuropathy is unknown. Determining whether there i...
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