Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polygenic risk of paclitaxel-induced peripheral neuropathy: a genome-wide association study

6 Dec 2022

Abstract excerpt

Abstract Background Genetic risk factors for chemotherapy-induced peripheral neuropathy (CIPN), a major dose-limiting side-effect of paclitaxel, are not well understood. Methods We performed a genome-wide association study (GWAS) in 183 paclitaxel-treated patients to identify genetic loci associated with CIPN assessed via comprehensive neuropathy phenotyping tools (patient-reported, clinical and neurological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Treatment and Pharmacology
Share to HER2/EGFR in Cancer Research
Share to Multiple Myeloma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36474270
DOI: 10.1186/s12967-022-03754-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polygenic risk of paclitaxel-induced peripheral neuropathy: a genome-wide association studyPMID 36474270Read ↗

A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.Semantic proximity Read ↗

Mechanistic insights into the pathogenesis of microtubule-targeting agent-induced peripheral neuropathy from pharmacogenetic and functional studies.Semantic proximity Read ↗

Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.Semantic proximity Read ↗

Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy.Semantic proximity Read ↗

Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).Semantic proximity Read ↗

Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.Semantic proximity Read ↗

Genetic variation in Charcot-Marie-Tooth genes contributes to sensitivity to paclitaxel-induced peripheral neuropathy.Semantic proximity Read ↗

Pharmacogenomics of chemotherapy induced peripheral neuropathy using an electronic health record-derived definition: a genome-wide association study.Semantic proximity Read ↗

Genomewide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy.Semantic proximity Read ↗

Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.Semantic proximity Read ↗

Identification of Rare Variants in Candidate Genes Associated with Chemotherapy-Induced Peripheral NeuropathySemantic proximity Read ↗

Detection of probable neuronal gene expression changes in skin biopsies from patients with paclitaxel-induced peripheral neuropathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.