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Article

Testing of candidate single nucleotide variants associated with paclitaxel neuropathy in the trial NCCTG N08C1 (Alliance).

Cancer medicine - 1 Apr 2016

Boora Ganesh K, Kanwar Rahul, Kulkarni Amit A, Abyzov Alexej, Sloan Jeff, Ruddy Kathryn J, Banck Michaela S, Loprinzi Charles L, Beutler Andreas S

Abstract excerpt

Paclitaxel-induced peripheral neuropathy (PIPN) cannot be predicted from clinical parameters and might have a pharmacogenomic basis. Previous studies identified single nucleotide variants (SNV) associated with PIPN. However, only a subset of findings has been confirmed to date in more than one study, suggesting a need for further re-testing and validation in additional clinical cohorts. Candidate PIPN-associated...

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Source

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Identifiers

PMID: 26763541
DOI: 10.1002/cam4.625
PMCID: PMC4831281

Genes

ABCB1
ABCC2
CACNB2
EPHA5
FGD4
PITPNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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