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Article

Genetic variation in Charcot-Marie-Tooth genes contributes to sensitivity to paclitaxel-induced peripheral neuropathy.

Pharmacogenomics - 1 Aug 2020

Chen Yongzhen, Fang Fang, Kidwell Kelley M, Vangipuram Kiran, Marcath Lauren A, Gersch Christina L, Rae James M, Hayes Daniel F, Lavoie Smith Ellen M, Henry N Lynn, Beutler Andreas S, Hertz Daniel L

Abstract excerpt

Aim: This study explored whether inherited variants in genes causing the hereditary neuropathy condition Charcot-Marie-Tooth disease are associated with sensitivity to paclitaxel-induced peripheral neuropathy (PN). Patients & methods: Hereditary neuropathy genes previously associated with risk of paclitaxel-induced PN were sequenced in paclitaxel-treated patients. Eight putative genetic predictors in five...

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Source

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Identifiers

PMID: 32700628
DOI: 10.2217/pgs-2020-0053
PMCID: PMC7444626

Genes

FZD3
ARHGEF10
FGD4
NXN
SBF2

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