Article
Association of Genetic Polymorphism with Taxane-induced Peripheral Neuropathy: Sub-analysis of a Randomized Phase II Study to Determine the Optimal Dose of 3-week Cycle Nab-Paclitaxel in Metastatic Breast Cancer Patients.
Acta medica Okayama - 1 Dec 2022
Abe Yuko, Taira Naruto, Kashiwabara Kosuke, Tsurutani Junji, Kitada Masahiro, Takahashi Masato, Kato Hiroaki, Kikawa Yuichiro, Sakata Eiko, Naito Yoichi, Hasegawa Yoshie, Saito Tsuyoshi, Iwasa Tsutomu, Takashima Tsutomu, Aihara Tomohiko, Mukai Hirofumi, Hara Fumikata, Shien Tadahiko, Doihara Hiroyoshi, Toyooka Shinichi
Abstract excerpt
Chemotherapy-induced peripheral neuropathy (CIPN) is an important clinical challenge that threatens patients' quality of life. This sub-study of the ABROAD trial investigated the influence of single nucleotide polymorphisms (SNPs) on CIPN, using genotype data from a randomized study to determine the optimal dose of a 3-week-cycle regimen of nab-paclitaxel (q3w nab-PTX) in patients with metastatic breast cancer...
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