Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.

doi:10.1158/1078-0432.CCR-16-0694

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Article

Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2017

Apellániz-Ruiz María, Tejero Héctor, Inglada-Pérez Lucía, Sánchez-Barroso Lara, Gutiérrez-Gutiérrez Gerardo, Calvo Isabel, Castelo Beatriz, Redondo Andrés, García-Donás Jesús, Romero-Laorden Nuria, Sereno María, Merino María, Currás-Freixes María, Montero-Conde Cristina, Mancikova Veronika, Åvall-Lundqvist Elisabeth, Green Henrik, Al-Shahrour Fátima, Cascón Alberto, Robledo Mercedes, Rodríguez-Antona Cristina

Abstract excerpt

Purpose: Neuropathy is the dose-limiting toxicity of paclitaxel and a major cause for decreased quality of life. Genetic factors have been shown to contribute to paclitaxel neuropathy susceptibility; however, the major causes for interindividual differences remain unexplained. In this study, we identified genetic markers associated with paclitaxel-induced neuropathy through massive sequencing of candidate...

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Identifiers

PMID: 27582484
DOI: 10.1158/1078-0432.CCR-16-0694

Genes

EPHA6
EPHA5
EPHA8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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