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Article

Crystal structure and receptor-interacting residues of MYDGF - a protein mediating ischemic tissue repair.

Nature communications - 26 Nov 2019

Ebenhoch Rebecca, Akhdar Abbas, Reboll Marc R, Korf-Klingebiel Mortimer, Gupta Priyanka, Armstrong Julie, Huang Yining, Frego Lee, Rybina Irina, Miglietta John, Pekcec Anton, Wollert Kai C, Nar Herbert

Abstract excerpt

Myeloid-derived growth factor (MYDGF) is a paracrine-acting protein that is produced by bone marrow-derived monocytes and macrophages to protect and repair the heart after myocardial infarction (MI). This effect can be used for the development of protein-based therapies for ischemic tissue repair, also beyond the sole application in heart tissue. Here, we report the X-ray structure of MYDGF and identify its...

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Identifiers

PMID: 31772377
DOI: 10.1038/s41467-019-13343-7
PMCID: PMC6879528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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