Article
Structural and functional aspects of RGD-containing protein antagonists of glycoprotein IIb-IIIa.
Current opinion in biotechnology - 1 Aug 1993
Lazarus R A, McDowell R S
Abstract excerpt
In the past few years, knowledge of the structure and function of RGD-containing protein antagonists of the platelet fibrinogen receptor glycoprotein IIb-IIIa has advanced rapidly. The RGD sequence is found at the apex of extended, solvent accessible, and conformationally flexible loops in proteins of vastly different structural frameworks. Conformation of the RGD epitope and the immediate surrounding sequence...
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