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Article

The role of the fibronectin IGD motif in stimulating fibroblast migration.

The Journal of biological chemistry - 7 Dec 2007

Millard Christopher J, Ellis Ian R, Pickford Andrew R, Schor Ana M, Schor Seth L, Campbell Iain D

Abstract excerpt

The motogenic activity of migration-stimulating factor, a truncated isoform of fibronectin (FN), has been attributed to the IGD motifs present in its FN type 1 modules. The structure-function relationship of various recombinant IGD-containing FN fragments is now investigated. Their structure is assessed by solution state NMR and their motogenic ability tested on fibroblasts. Even conservative mutations in the IGD...

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Identifiers

PMID: 17921136
DOI: 10.1074/jbc.M707532200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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